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Power Analysis of Cutoff-Based Randomized Clinical TrialsNew England Medical Center
Cornell University
Cornell University A cutoff-based randomized clinical trial couples cutoff-based assignment on an appropriate covariate with random assignment to help balance ethical and scientific concerns in certain situations. A statistical power algorithm based on the Fisher Z method is developed that is particular to and inclusive of cutoff-based random clinical trials and the single cutoff-point (regression-discontinuity) design, which has no randomization. This article quantifies power and sample size estimates for varying levels of randomization and cutoff-based assignment. Although more randomization engenders greater statistical power, less randomization requires a much larger increase in sample size for small treatment effects.
Evaluation Review, Vol. 18, No. 2,
141-152 (1994) This article has been cited by other articles:
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